NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
Part No. RXSOL-60-6605-027
NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
Key details
| Part number | RXSOL-60-6605-027 |
|---|---|
| Standard packing | 0.00 Box |
| Supply locations | NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman. Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada. NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS is available in small packing as well as in bulk. Buy premium quality NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS and other lab chemicals from one of the most trusted brands. |
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<em><strong><span style="font-family:georgia,serif;"><span style="font-size:14px;">It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine. As DIPEA is hindered and poorly nucleophilic, it does not compete with the nucleophilic amine in the coupling reaction.</span></span></strong></em></p>
<p>
<span style="font-family:georgia,serif;"><strong><em><span style="font-size:14px;">DIPEA is a good base used for deprotonation of carboxylic acid in peptides/amino acids to give you the intermediate carboxylate. It is added based on molar ratio.</span></em></strong></span></p>
<p>
<strong><em><span style="font-family:georgia,serif;"><span style="font-size:14px;">Diisopropylamine is purified by heating to reflux over sodium hydroxide (NaOH) for 3–12 hr, followed by simple distillation from NaOH. 4. Butyllithium in hexanes (2.5 M) is purchased from Aldrich Chemical Company, Inc., and titrated using diphenylacetic acid.</span></span></em></strong></p>
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