PHTHALAMIDE FOR SYNTHESIS
Part No. RXSOL-60-6605-237
PHTHALAMIDE FOR SYNTHESIS
Key details
| Part number | RXSOL-60-6605-237 |
|---|---|
| Standard packing | 0.00 Box |
| Supply locations | PHTHALAMIDE FOR SYNTHESIS manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman. Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada. PHTHALAMIDE FOR SYNTHESIS is available in small packing as well as in bulk. Buy premium quality PHTHALAMIDE FOR SYNTHESIS and other lab chemicals from one of the most trusted brands. |
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<em><span style="font-family:georgia,serif;"><span style="font-size:16px;">The Gabriel Synthesis Uses A “Protected” Amine (Phthalimide) In An SN2 Reaction That Does Not Undergo Over-Alkylation. ... In phthalimide, a nitrogen is flanked by two carbonyl groups. This means that the N-H is a lot more acidic than it normally would be, because the resulting anion will be resonance stabilized.</span></span></em></p>
<p style="text-align: justify;">
<em><span style="font-family:georgia,serif;"><span style="font-size:16px;">Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.</span></span></em></p>
<p style="text-align: justify;">
<em><span style="font-family:georgia,serif;"><span style="font-size:16px;">The Gabriel method generally doesn't work with secondary alkyl halides. Another disadvantage of this synthesis is that using acidic/basic hydrolysis gives a low yield whereas the usage of hydrazine can make the conditions of the synthesis relatively harsh.</span></span></em></p>
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